3M-011

• Description:

  3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. 3M-011 significantly inhibits H3N2 influenza viral replication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune responses during radiotherapy. 3M-011 strongly has antitumor action[1][2][3].

• UNSPSC:

  12352005

• Target:

  Influenza Virus; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/3m-011.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CS(=O)(NC(C)(C)CN1C(COCC)=NC2=C1C3=CC=CC=C3N=C2N)=O

• Molecular Formula:

  C18H25N5O3S

• Molecular Weight:

  391.49

• References & Citations:

  [1]Dumitru CD, et al. NK1.1+ cells mediate the antitumor effects of a dual Toll-like receptor 7/8 agonist in the disseminated B16-F10 melanoma model. Cancer Immunol Immunother. 2009 Apr;58 (4) :575-87.|[2]Hammerbeck DM, et al. Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res. 2007 Jan;73 (1) :1-11.|[3]Schölch S, et al. Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors. Oncotarget. 2015 Mar 10;6 (7) :4663-76.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TLR7; TLR8

• CAS Number:

  [642473-62-9]