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AN-3485

CAT: 0804-HY-18325-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18325-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity[1][2].
CAS Number
1213827-99-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Interleukin Related; NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/AN-3485.html
Concentration
10mM
Purity
97.38
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1
Molecular Formula
C14H13BClNO3
Molecular Weight
289.52
Precautions
H302, H315, H319
References & Citations
[1]Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344 (2) :436-46.|[2]Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; TLR2; TLR3; TLR4

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