BMAP 28 (bovine)

• UNSPSC Description:

  BMAP 28, bovine is an antibacterial peptide. BMAP 28, bovine exhibits antimicrobial activity against gram-positive and gram-negative bacteria, by increasing cell membrane permeability, and causing leakage of cell contents. BMAP 28, bovine exhibits cytotoxicity to cancer cells and activated human lymphocytes. BMAP 28, bovine induces apoptosis through depolarization of mitochondrial membrane potential[1][2][3].

• Target Antigen:

  Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/bmap-28-bovine.html

• Smiles:

  C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC3)C(C)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC2)=O)=O)CCCCN)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CN)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CO)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)[C@H](CC)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)C)=O)C=4C=5C(NC4)=CC=CC5

• Molecular Weight:

  3131.85

• References & Citations:

  [1]Brogden KA, et al., Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents. 2003 Nov;22(5):465-78. |[2]Guo Y, et al., A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine (Baltimore). 2018 Oct;97(42):e12832. |[3]Risso A, et al., BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol Cell Biol. 2002 Mar;22(6):1926-35.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  939963-76-5