5-Fluoroindole

CAT: 0804-HY-40156-01Size: 5 gDry Ice: NoHazardous: No
CAT#:0804-HY-40156-01Size:5 g
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Description
5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC50 of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker[1][2][3].
CAS Number
[399-52-0]
UNSPSC
12352200
Hazard Statement
H315, H319, H335
Target
Apoptosis; Bacterial; Reactive Oxygen Species (ROS)
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/5-fluoroindole.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C2NC=CC2=C1
Molecular Formula
C8H6FN
Molecular Weight
135.14
Precautions
H315, H319, H335
References & Citations
[1]Neves CE, et al., 5-Fluoroindole Reduces the Bacterial Burden in a Murine Model of Mycobacterium tuberculosis Infection. ACS Omega. 2024 Jul 16;9 (30) :32969-32979. |[2]Zhang C, et al. 5-Fluoroindole Inhibits Its Putative Target Methionine Synthase and Pseudomonas syringae pv. actinidiae Virulence. J Agric Food Chem. 2025 Jul 2;73 (26) :16193-16204. |[3]Pan B, et al. Fluorine-19 labeling of the tryptophan residues in the G protein-coupled receptor NK1R using the 5-fluoroindole precursor in Pichia pastoris expression. J Biomol NMR. 2024 Sep;78 (3) :133-138.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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