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MK-3168 (12C)

CAT: 0804-HY-161965Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161965Size:1 Each
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Description
MK-3168 (12C) is a FAAH inhibitor with IC50 values of 1.0, 5.5, 1.7 nM for human, rhesus, rat, respectively. MK-3168 shows good brain uptake and FAAH-specific signal. 11C MK-3168 can be used as FAAH PET tracer[1].
CAS Number
1242441-26-4
UNSPSC
12352005
Target
FAAH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mk-3168-12c.html
Smiles
ClC1=CN=C(SC2=C(C3=CC=C([C@H]4C[C@@H]4C(N(C)C)=O)C=C3)N=CN2C)C=C1
Molecular Formula
C21H21ClN4OS
Molecular Weight
412.94
References & Citations
[1]Liu P, et al. Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. ACS Med Chem Lett. 2013 Apr 20;4 (6) :509-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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