Menthone

• Description:

  Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H319, H334, H412

• Target:

  NF-κB; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/menthone.html

• Concentration:

  10mM

• Purity:

  99.96

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C(C(C)C)CCC(C)C1

• Molecular Formula:

  C10H18O

• Molecular Weight:

  154.25

• Precautions:

  H302, H319, H334, H412

• References & Citations:

  [1]Mauricio G Zaia, et al. Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170.|[2]Chen X, et al. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis. J Nat Prod. 2022 Apr 22;85 (4) :1109-1117. |[3]Su YH, et al. Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. Eur J Pharmacol. 2022 Sep 15;931:175222.|[4]Chen X, et al. Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis. Int Immunopharmacol. 2022 Nov;112:109228.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Schistosome

• CAS Number:

  [10458-14-7]