Menthone

• Description :

  Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis[1][2].

• CAS Number :

  [10458-14-7]

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H319, H334, H412

• Target :

  NF-κB; Parasite

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/menthone.html

• Concentration :

  10mM

• Purity :

  99.96

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C(C)C)CCC(C)C1

• Molecular Formula :

  C10H18O

• Molecular Weight :

  154.25

• Precautions :

  H302, H319, H334, H412

• References & Citations :

  [1]Mauricio G Zaia, et al. Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170.|[2]Chen X, et al. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis. J Nat Prod. 2022 Apr 22;85 (4) :1109-1117. |[3]Su YH, et al. Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. Eur J Pharmacol. 2022 Sep 15;931:175222.|[4]Chen X, et al. Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis. Int Immunopharmacol. 2022 Nov;112:109228.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Schistosome