(-)-Menthol

• UNSPSC Description:

  (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

• Target Antigen:

  Endogenous Metabolite; TRP Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_-_-Menthol.html

• Purity:

  99.88

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 1.89 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1

• Molecular Weight:

  156.27

• References & Citations:

  [1]Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  2216-51-5