(-) -Menthol

• Description :

  (-) -Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319

• Target :

  Endogenous Metabolite; TRP Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_-_-Menthol.html

• Purity :

  99.88

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 1.89 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1

• Molecular Formula :

  C10H20O

• Molecular Weight :

  156.27

• Precautions :

  H315, H319

• References & Citations :

  [1]Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D (3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44 (2) :125-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [2216-51-5]