(-) -Menthol

• Description:

  (-) -Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319

• Target:

  Endogenous Metabolite; TRP Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_-_-Menthol.html

• Purity:

  99.88

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 1.89 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O[C@H]1[C@H] (C (C) C) CC[C@@H] (C) C1

• Molecular Formula:

  C10H20O

• Molecular Weight:

  156.27

• Precautions:

  H315, H319

• References & Citations:

  [1]Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D (3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44 (2) :125-30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  2216-51-5