DL-Menthol

CAT: 0804-HY-Y1683-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-Y1683-01Size:500 mg
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Description
DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production[1][2].
CAS Number
[89-78-1]
Product Name Alternative
Racementhol
UNSPSC
12352211
Hazard Statement
H315, H319, H402
Target
GABA Receptor
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dl-menthol.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)
Smiles
C[C@H]1C[C@@H](O)[C@H](C(C)C)CC1
Molecular Formula
C10H20O
Molecular Weight
156.27
Precautions
H315, H319, H402
References & Citations
[1]Kozlovich S, et al. Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL. Drug Metab Dispos. 2019 Dec;47 (12) :1388-1396.|[2]Kasai, Masanori, et al. Menthol induces surgical anesthesia and rapid movement in fishes. Open Neuroscience Journal 8 (2014) : 1-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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