Menthol

• UNSPSC Description :

  Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice[1][2][3].

• Target Antigen :

  Calcium Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/menthol.html

• Purity :

  99.44

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  OC1C(C(C)C)CCC(C)C1

• Molecular Weight :

  156.27

• References & Citations :

  [1]NicolettaGaleotti, et al. Menthol: a natural analgesic compound. Neuroscience Letters. 2002 Apr.|[2]Ha MA, et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One. 2015 Feb 13;10(2):e0117128.|[3]Fan L, et al. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tob Control. 2016 Nov;25(Suppl 2):ii50-ii54.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information :

  Launched

• CAS Number :

  [1490-04-6]