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NLRP3/AIM2-IN-3

CAT: 1568-C03572-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03572-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1787787-60-3
Target
NLRP3
Applications
Immunology & Inflammation
Molecular Formula
C16H14N2O2
Additionnal Information
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis. It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 μM. It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC, effectively preventing ASC oligomerization and blocking inflammasome assembly.

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