CP-601927

• UNSPSC Description:

  CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties[1][2].

• Target Antigen:

  nAChR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cp-601927.html

• Smiles:

  FC(C1=CC=C2[C@@H](C3)CNC[C@@H]3C2=C1)(F)F

• Molecular Weight:

  227.229

• References & Citations:

  [1]Campion SN, et al. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011;92(4):323-332.|[2]Mineur YS, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011;22(4):291-299.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  357425-02-6