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Ethonafide

CAT: 0804-HY-117543Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117543Size:1 Each
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Description
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β[1].
CAS Number
[160554-87-0]
Product Name Alternative
AMP-53; 6-Ethoxyazonafide
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ethonafide.html
Smiles
O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
Molecular Formula
C22H22N2O3
Molecular Weight
362.42
References & Citations
[1]Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321 (3) :1109-17.|[2]S M Sami, et al. 6- and 7-substituted 2-[2'- (dimethylamino) ethyl]-1,2-dihydro-3H-dibenz[de, h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39 (8) :1609-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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