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Ethonafide

CAT: 0931-T70222-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T70222-01Size:25 mg
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CAS Number
175293-23-9
Target
Others
Related Pathways
Others
Bioactivity
Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G (2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -be......
Smiles
O=C1C2=C3C(=C(OCC)C=4C2=CC=CC4)C=CC=C3C(=O)N1CCN(C)C
Molecular Formula
C22H22N2O3
Molecular Weight
362.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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