Ethionamide

• Description:

  Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity[1][2][3][4].

• Product Name Alternative:

  2-Ethylthioisonicotinamide

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H361

• Target:

  Antibiotic; Bacterial

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Ethionamide.html

• Purity:

  99.97

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  S=C(C1=CC(CC)=NC=C1)N

• Molecular Formula:

  C8H10N2S

• Molecular Weight:

  166.25

• Precautions:

  H302, H361

• References & Citations:

  [1]Vannelli, T.A., A. Dykman, and P.R. Ortiz de Montellano, The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem, 2002. 277 (15) : p. 12824-9.|[2]Quemard, A., G. Laneelle, and C. Lacave, Mycolic acid synthesis: a target for ethionamide in mycobacteria? Antimicrob Agents Chemother, 1992. 36 (6) : p. 1316-21.|[3]Marilyn C Henderson, et al. Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicol Appl Pharmacol. 2008 Dec 15;233 (3) :420-7.|[4]Amy L Palmer, et al. Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse. Pharmaceuticals (Basel) . 2012;5 (11) :1147-59.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [536-33-4]