BIBN-99

• Description :

  BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bibn-99.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCC(C)(C(N(CC)CCCC1CCN(CC1)CC(N2C3=NC=CC=C3NC(C4=CC(Cl)=CC=C42)=O)=O)=O)C

• Molecular Formula :

  C31H42ClN5O3

• Molecular Weight :

  568.15

• References & Citations :

  [1]Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242 (1) :23-30.|[2]Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686 (1) :37-43.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [145301-48-0]