ML318

CAT: 0804-HY-129123-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-129123-01Size:5 mg
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Description
ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions[1].
CAS Number
[1610516-67-0]
UNSPSC
12352005
Hazard Statement
H301
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml318.html
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC(C1=CC=C(F)C=C1)C2=NC(C(F)(F)F)=CC=C2
Molecular Formula
C14H8F4N2
Molecular Weight
280.22
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Jacqueline M Wurst, et al. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. ACS Chem Biol. 2014 Jul 18;9 (7) :1536-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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