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ML314

CAT: 0804-HY-16639-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16639-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML314 is a potent, BBB-penetrant and β-arrestin biased molecule agonist of NTR1 (EC50 = 1.9 μM) . ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions[1][2].
CAS Number
[1448895-09-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR35 ; Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ML314.html
Purity
99.52
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=CC=CC=C1N2CCN(C3=C4C=C(OC)C(OC)=CC4=NC(C5CC5)=N3)CC2
Molecular Formula
C24H28N4O3
Molecular Weight
420.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Hershberger P, et al. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists) . Probe Reports from the NIH Molecular Libraries Program|[2]Barak, L. S., et al., (2016) . ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS chemical biology, 11 (7), 1880–1890.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NTR1

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Alternative Products

CatalogName
MBS5764332-01ML314
A13570-25ML314 25mg
A13570-5ML314 5mg
A13570-50ML314 50mg
A13570-10ML314 10mg

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