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ML381

CAT: 0804-HY-101839-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101839-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM) . ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies[1][2].
CAS Number
1623481-80-0
Product Name Alternative
VU0488130
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml381.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC(COC2=CC=CC(C(C)=O)=C2)=C1)N(C)[C@H](C3=NC=CC=C3)C
Molecular Formula
C21H21N3O4
Molecular Weight
379.41
Precautions
H302, H315, H319
References & Citations
[1]Gentry PR, et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR) -selective M5-orthosteric antagonist, VU0488130 (ML381) : a novel molecular probe. ChemMedChem. 2014 Aug;9 (8) :1677-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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