ML378

CAT: 0804-HY-120126Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120126Size:1 Each
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Description
ML378 (CID71710938) is a dual LYPLA1 and LYPLA2 inhibitor, with IC50s of 122 nM and 245 nM respectively. ML378 also shows potent inhibition of ABHD6 (IC50 = 3.15 nM) . ML378 can be used for elucidating the patho/physiological roles of the LYPLA1 and LYPLA2[1].
CAS Number
[1831135-21-7]
Product Name Alternative
CID71710938; JJH-254
UNSPSC
12352005
Target
Phospholipase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C(N1CCC(CCC2=CC=C(Cl)C=C2)CC1)ON(C3=O)C(N4C3CN(C(N5CCOCC5)=O)CC4)=O
Molecular Formula
C25H32ClN5O6
Molecular Weight
534.00
References & Citations
[1]Hulce JJ, et al. An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2) 2013 Dec 9 [Updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010-.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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