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GA-017

CAT: 1568-C01502-04Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C01502-04Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2351906-74-4
SKU
C01502-5mg
Target
LATS
Applications
Hippo
Smiles
CC\C (=N\NC (=O) NCC1=CC (=CC=C1) O) C2=C (O) C (=C (O) C=C2) C
Additionnal Information
GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
Storage Conditions
3 years -20°C powder

Chemical Information

CID 147467531
CAS Number2351906-74-4
PubChem CID147467531
IUPAC Name1-[(Z)-1-(2,4-dihydroxy-3-methylphenyl)propylideneamino]-3-[(3-hydroxyphenyl)methyl]urea
Molecular FormulaC18H21N3O4
Molecular Weight343.4
XLogP2.5
Topological Polar Surface Area114
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity471
SMILES
CC/C(=N/NC(=O)NCC1=CC(=CC=C1)O)/C2=C(C(=C(C=C2)O)C)O
InChI
InChI=1S/C18H21N3O4/c1-3-15(14-7-8-16(23)11(2)17(14)24)20-21-18(25)19-10-12-5-4-6-13(22)9-12/h4-9,22-24H,3,10H2,1-2H3,(H2,19,21,25)/b20-15-
InChIKey
FBCPIOAXERAOIA-HKWRFOASSA-N
Chemical Structure
2D Structure
2D structure of CID 147467531
CAS: 2351906-74-4
CID: 147467531
Formula: C18H21N3O4
MW: 343.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.4
XLogP32.5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass343.15320616
Monoisotopic Mass343.15320616
Topological Polar Surface Area114 Ų
Heavy Atom Count25
Formal Charge0
Complexity471
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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