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AZD0364 (ATG-017)

CAT: 1568-C13608-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1568-C13608-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2097416-76-5
SKU
C13608-2mg
Target
ERK
Applications
MAPK
Smiles
CC1=CN=C (N=C1C2=CN3CC (N (C (=O) C3=N2) CC4=CC (=C (C=C4) F) F) COC) NC5=CC=NN5C
Molecular Formula
C24H24F2N8O2
Additionnal Information
AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.
Storage Conditions
3 years -20°C powder

Chemical Information

Tizaterkib

Tizaterkib is a small molecule drug. The usage of the INN stem '-terkib' in the name indicates that Tizaterkib is a extracellular signal-regulated kinase (ERK) inhibitor. Tizaterkib is under investigation in clinical trial NCT04305249 (Safety and Preliminary Efficacy of ATG-017 Monotherapy or Combination Therapy With Nivolumab in Advanced Solid Tumors and Hematological Malignancies). Tizaterkib has a monoisotopic molecular weight of 494.2 Da.

CAS Number2097416-76-5
PubChem CID129116690
IUPAC Name(6R)-7-[(3,4-difluorophenyl)methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one
Molecular FormulaC24H24F2N8O2
Molecular Weight494.5
XLogP2
Topological Polar Surface Area103
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity768
SMILES
CC1=CN=C(N=C1C2=CN3C[C@@H](N(C(=O)C3=N2)CC4=CC(=C(C=C4)F)F)COC)NC5=CC=NN5C
InChI
InChI=1S/C24H24F2N8O2/c1-14-9-27-24(30-20-6-7-28-32(20)2)31-21(14)19-12-33-11-16(13-36-3)34(23(35)22(33)29-19)10-15-4-5-17(25)18(26)8-15/h4-9,12,16H,10-11,13H2,1-3H3,(H,27,30,31)/t16-/m1/s1
InChIKey
HVIGNZUDBVLTLU-MRXNPFEDSA-N
Chemical Structure
2D Structure
2D structure of Tizaterkib
CAS: 2097416-76-5
CID: 129116690
Formula: C24H24F2N8O2
MW: 494.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight494.5
XLogP32
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass494.19902836
Monoisotopic Mass494.19902836
Topological Polar Surface Area103 Ų
Heavy Atom Count36
Formal Charge0
Complexity768
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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