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24-Methylenecholesterol

CAT: 0804-HY-133968-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133968-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth[1][2][3].
CAS Number
474-63-5
Product Name Alternative
Ostreasterol
UNSPSC
12352211
Target
Acyltransferase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/24-methylenecholesterol.html
Purity
99.48
Solubility
10 mM in DMSO
Smiles
C=C(C(C)C)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C28H46O
Molecular Weight
398.66
References & Citations
[1]Sun Y, et al. Sterols from Mytilidae show anti-aging and neuroprotective effects via anti-oxidative activity. Int J Mol Sci. 2014 Nov 25;15 (12) :21660-73.|[2]Chakrabarti P, et al. Changes in Honey Bee Head Proteome in Response to Dietary 24-Methylenecholesterol. Insects. 2020 Oct 29;11 (11) :743.|[3]Tabas I, et al. The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction. J Clin Invest. 1989 Dec;84 (6) :1713-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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