ATN-224

• Description :

  ATN-224 is an orally active Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.

• Product Name Alternative :

  Bis (choline) tetrathiomolybdate

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  SOD

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ATN-224.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  OCC[N+](C)(C)C.OCC[N+](C)(C)C.[S-][Mo]([S-])(=S)=S

• Molecular Formula :

  C10H28MoN2O2S4

• Molecular Weight :

  432.56

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12 (16) :4974-82.|[2]Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-na?ve prostate cancer. Urol Oncol. 2013 Jul;31 (5) :581-8.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [649749-10-0]