Aldosterone

Aldosterone

• Alternative Name: E64d; E64c ethyl ester
• CAS Number: 52-39-1
• UNSPSC Description: Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
• Target Antigen: Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/aldosterone.html
• Purity: 99.90
• Solubility: DMSO : 50 mg/mL (ultrasonic)|Ethanol : 33.33 mg/mL (ultrasonic)
• Smiles: C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(CO)=O)CC[C@@]4([H])[C@]3([H])CCC1=CC(CC2)=O
• Molecular Weight: 360.44
• References & Citations: [1]Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223.|[2]Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.|[3]Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290(2):69-73.|[4]Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9(10):e111104.|[5]Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched