Aldosterone

• Description:

  Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

• Product Name Alternative:

  E64d; E64c ethyl ester

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H332

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/aldosterone.html

• Purity:

  99.90

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |Ethanol : 33.33 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(CO)=O)CC[C@@]4([H])[C@]3([H])CCC1=CC(CC2)=O

• Molecular Formula:

  C21H28O5

• Molecular Weight:

  360.44

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71 (2) :218-223.|[2]Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.|[3]Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290 (2) :69-73.|[4]Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9 (10) :e111104.|[5]Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [52-39-1]