Aldosterone-d7

CAT: 0804-HY-113313S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113313S1Size:1 mg
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Description
Aldosterone-d7 is the deuterium labeled Aldosterone. Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].
UNSPSC
12352211
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Purity
99.78
Solubility
DMSO : 100mg/mL (ultrasonic) |Ethanol : 33.33mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@]3([H])[C@@H](O)C[C@]4(C=O)[C@@H](C(C([2H])([2H])O)=O)CC[C@@]4([H])[C@]3([H])CC([2H])([2H])C1=C([2H])C(C([2H])([2H])C2)=O
Molecular Formula
C21H21D7O5
Molecular Weight
367.49
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71 (2) :218-223.|[3]Cannavo A, et al. Aldosterone and Mineralocorticoid Receptor System in Cardiovascular Physiology and Pathophysiology. Oxid Med Cell Longev. 2018 Sep 19;2018:1204598.|[4]Ikeda U, et al. Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Eur J Pharmacol. 1995 Jul 18;290 (2) :69-73.|[5]Martín-Fernández B, et al. Beneficial effects of proanthocyanidins in the cardiac alterations induced by aldosterone in ratheart through mineralocorticoid receptor blockade. PLoS One. 2014 Oct 29;9 (10) :e111104.|[6]Dinh QN, et al. Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor. Brain Res. 2016 Apr 15;1637:146-153.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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