5,7-Dihydroxychromone
CAT:
804-HY-N1970-04
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
5,7-Dihydroxychromone
- CAS Number: 31721-94-5
- UNSPSC Description: 5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].
- Target Antigen: Arenavirus; Caspase; Keap1-Nrf2; PARP
- Type: Natural Products
- Related Pathways: Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Epigenetics;NF-κB
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/5-7-dihydroxychromone.html
- Purity: 99.94
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C1C=COC2=CC(O)=CC(O)=C12
- Molecular Weight: 178.143
- References & Citations: [1]Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported