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5,7-Dihydroxychromone

CAT: 0804-HY-N1970-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1970-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA) -induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells[1].
CAS Number
31721-94-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Arenavirus; Caspase; Keap1-Nrf2; PARP
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-7-dihydroxychromone.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=COC2=CC(O)=CC(O)=C12
Molecular Formula
C9H6O4
Molecular Weight
178.14
Precautions
H315, H319
References & Citations
[1]Kim DW, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; PARP

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