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SH3G1 rabbit pAb

CAT: 0855-ES13128-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13128-01Size:50 µL
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Background
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Description
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
UniProt
Q99961
Swiss Prot
Q99961
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human SH3G1 AA range: 112-162
Target
SH3G1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Cell projection, podosome . Associated with postsynaptic endosomes in hippocampal neurons. .
Gene ID (Human)
6455

UniProtKB · Q99961

Endophilin-A2

SH3G1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99961
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SH3GL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DRA1, E7EVZ4, M0QZV5, Q99668
Protein keywords

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Cellular component

Cell junctionCell projectionCytoplasmEndosomeMembrane

Domain

Coiled coilSH3 domain

Biological process

Endocytosis

Ligand

Lipid-binding

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Disease

Proto-oncogene

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