Anticancer agent 194

• Description :

  Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; Ferroptosis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-194.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCCCl)N1C2=CC=C(OC)C=C2NCC1

• Molecular Formula :

  C12H16ClN3O2

• Molecular Weight :

  269.73

• References & Citations :

  [1]Tingting Liang, et al. Discovery of novel urea derivatives as ferroptosis and autophagy inducer for human colon cancer treatment. Eur J Med Chem. 2024 Feb 24:268:116277.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2767204-90-8]