Ent- (+) -Verticilide

• Description:

  Ent- (+) -verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent- (+) -verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent- (+) -verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ent-plus-verticilide.html

• Purity:

  99.91

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC[C@H]1C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O[C@H](C(N([C@@H](C(O1)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

• Molecular Formula:

  C44H76N4O12

• Molecular Weight:

  853.09

• References & Citations:

  [1]Suzanne M Batiste, et al. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc Natl Acad Sci U S A. 2019 Mar 12;116 (11) :4810-4815.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [2056011-05-1]