Verticilide

• Description :

  Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM) ) [1].

• CAS Number :

  [693778-57-3]

• UNSPSC :

  12352209

• Target :

  Calcium Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/verticilide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCC[C@@H](OC([C@@H](N(C([C@H](OC([C@@H](N(C1=O)C)C)=O)CCCCC)=O)C)C)=O)C(N([C@H](C(O[C@@H](C(N([C@H](C(O[C@@H]1CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

• Molecular Formula :

  C44H76N4O12

• Molecular Weight :

  853.09

• References & Citations :

  [1]Kazuro Shiomi, et al. Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J Antibiot (Tokyo) . 2010 Feb;63 (2) :77-82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported