Verticilide

• Description:

  Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM) ) [1].

• UNSPSC:

  12352209

• Target:

  Calcium Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/verticilide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC[C@@H](OC([C@@H](N(C([C@H](OC([C@@H](N(C1=O)C)C)=O)CCCCC)=O)C)C)=O)C(N([C@H](C(O[C@@H](C(N([C@H](C(O[C@@H]1CCCCC)=O)C)C)=O)CCCCC)=O)C)C)=O

• Molecular Formula:

  C44H76N4O12

• Molecular Weight:

  853.09

• References & Citations:

  [1]Kazuro Shiomi, et al. Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J Antibiot (Tokyo) . 2010 Feb;63 (2) :77-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [693778-57-3]