Ent- (+) -Verticilide

• Target:

  Calcium Channel

• Related Pathways:

  Metabolism|||Membrane transporter/Ion channel

• Bioactivity:

  Ent- (+) -verticilide is an effective and specific inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels, demonstrating antiarrhythmic properties. It suppresses RyR2-mediated diastolic Ca2+ leak and shows greater potency and a unique action mechanism compared to Dantrolene and Tetracaine. ent- (+) -verticilide serves as a valuable tool for exploring the therapeutic potential of addressing RyR2 hyperactivity in cardiac and neurological conditions [1].

• Smiles:

  C(CCCC)[C@H]1C(=O)N(C)[C@H](C)C(=O)O[C@@H](CCCCC)C(=O)N(C)[C@H](C)C(=O)O[C@@H](CCCCC)C(=O)N(C)[C@H](C)C(=O)O[C@@H](CCCCC)C(=O)N(C)[C@H](C)C(=O)O1

• Molecular Formula:

  C44H76N4O12

• Molecular Weight:

  853.09

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2056011-05-1