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5-Carboxamidotryptamine

CAT: 0804-HY-135555-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135555-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4].
CAS Number
74885-09-9
Product Name Alternative
5-CT
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-carboxamidotryptamine.html
Purity
98.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(NC=C2CCN)C=C1)N
Molecular Formula
C11H13N3O
Molecular Weight
203.24
Precautions
H315, H319, H320
References & Citations
[1]Saxena PR, et al. Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia. 1989;9 Suppl 9:15-22.|[2]Saxena PR, et al. From serotonin receptor classification to the antimigraine drug sumatriptan. Cephalalgia. 1992 Aug;12 (4) :187-96.|[3]Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44 (8) :1031-7.|[4]Hurley PT, et al. Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells. Br J Pharmacol. 1998 Jul;124 (6) :1238-44.|[5]Connor HE, et al. 5-Carboxamidotryptamine is a selective agonist at 5-hydroxytryptamine receptors mediating vasodilatation and tachycardia in anaesthetized cats. Br J Pharmacol. 1986 Feb;87 (2) :417-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT5 Receptor;5-HT7 Receptor; mLAG-3; MUC3; Prostaglandin D Synthase

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