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Anti-Grb2 Antibody

CAT: 1549-GM3311Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1549-GM3311Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Crk and Grb2 family adaptor proteins are involved in a variety of cell signaling pathways related to human diseases. These adaptors have Src homology 2 (SH2) and Src homology 3 (SH3) domains, which are docking sites for several signaling proteins, including receptors, kinases, and GTPase regulators. In addItion, other protein-protein interactions may also utilize Crk and Grb2 domain interactions to modulate cell signaling pathways. The DOCK family of proteins (DOCK3, DOCK4, and DOCK5) can interact with Crk and may be important Crk effector proteins. The cell cycle regulator p27Kip1 can interact with Grb2, and this implicates Grb2 activity in cell signaling pathways that alter cell cycle progression.
Description
Our Grb2 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Grb2 and is protein a purified. It is great for use in ELISA, WB, ICC, IP.
Short Description
Our Grb2 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Grb2 and is Protein A purified. It is great for use in WB, ICC, IP.
Synonyms
Grb
Gene Name
GRB2
UniProt
P62994
Reactivity
Human, Mouse, and Rat
Immunogen
Clone (M331) was generated from a full length recombinant rat Grb2 protein. This sequence has high homology to human and mouse Grb2.
Target
Grb2
Clonality
Monoclonal
Clone
M331
Conjugation
Unconjugated
Applications
ELISA, WB, ICC, IP
Field of Research
Cell Signaling, Growth Factor Signaling, Oncoproteins
Format
Protein A Purified
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Modification
GOmAb
Molecular Weight
24
Precautions
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Shipping Conditions
Blue Ice
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Notes
Protein A purified culture supernatant.
WB Dilution
1:1000
IP Dilution
1:50
Specificity
This antibody detects a 24 kDa* protein corresponding to the molecular mass of Grb2 on SDS-PAGE immunoblots of rat PC12.
ICC Dilution
1:50
Quality Control
Western blots performed on each lot.
Host or Source
Mouse
Physical Properties
Liquid
Isotype
IgG1
Immunogen Species
Rat
WB Quality Control
Quality Control: WB
RRID
AB_2113024

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