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Anti-ShcA Antibody

CAT: 1549-SP1331Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1549-SP1331Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then, a number of studies in multiple systems have implicated a role for Shc in many different types of signal transduction including growth factor, antigen, cytokine, G-protein, hormone, and integrin receptor signaling. In addition to the ubiquitous ShcA, there are two other shc gene products, ShcB and ShcC, which are predominantly expressed in neuronal cells. ShcA knockout mice are embryonic lethal and have clearly suggested an important role for ShcA in vivo. An important role for Shc in the activation of MAPK pathway has been established. Thus, Shc adapter proteins are critical components of signal transduction pathways involved in many different cellular processes.
Description
Our ShcA primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rabbit, and rat ShcA and is antigen affinity purified. It is great for use in ELISA, WB, ICC.
Short Description
Our ShcA primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rabbit, and rat ShcA and is antigen affinity purified. It is great for use in WB, ICC.
Synonyms
SH2 C1, SHC
Gene Name
SHC1
UniProt
P29353
Reactivity
Human, Mouse, Rabbit, and Rat
Immunogen
A recombinant protein that included amino acid residues within the C-terminal region of human ShcA. This sequence has high homology with similar regions in rat and mouse ShcA.
Target
ShcA
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
ELISA, WB, ICC
Field of Research
Cell Signaling, Neurodegenerative Disease, Alzheimer's Disease, Oncoproteins
Format
Antigen Affinity Purified
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Molecular Weight
45/52/66
Precautions
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Shipping Conditions
Blue Ice
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Notes
Affinity purified rabbit serum
WB Dilution
1:1000
Specificity
The antibody detects 46/52/66 kDa* bands corresponding to the molecular weight of ShcA variants on SDS-PAGE immunoblots of A431 cells. It also detects ShcA in human Jurkat, HeLa, and SKN-SH cells, as well as rat brain tissue and rabbit spleen fibroblasts.
ICC Dilution
1:50
Quality Control
Western blots performed on each lot.
Host or Source
Rabbit
Physical Properties
Liquid
Isotype
IgG
Immunogen Species
Human
WB Quality Control
Quality Control: WB
RRID
AB_2188007

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