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Anti-Grb2 Polyclonal Antibody

CAT: 0793-30-1387-0.1Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0793-30-1387-0.1Size:0.1 mg
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Description
Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.
Product Name Alternative
GRB2||ASH
Gene Name
GRB2
Gene ID
2885
UniProt
P62993
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217) .
Target Antigen
Grb2
Clonality
Polyclonal
Applications
WB
Purification
Purified from rabbit serum by affinity chromatography
Format
Purified
Storage Conditions
Store at 2-8°C. Do not freeze.
Applications Notes
Western Blotting Recommended dilution: 1 μg/mL Positive control: RAMOS human Burkitt lymphoma cell line
Isotype
Rabbit IgG

UniProtKB · P62993

Growth factor receptor-bound protein 2

GRB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P62993
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GRB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
P29354, Q14450, Q63057, Q63059
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndosomeGolgi apparatusNucleus

Biological process

Host-virus interaction

Domain

RepeatSH2 domainSH3 domain

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