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Polyclonal Antibody to Otx2

CAT: 0793-11-12025-25Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0793-11-12025-25Size:25 µg
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Description
Otx2 encodes a transcription factor that plays a critical role in craniofacial development and anterior brain morphogenesis. Otx2 homologs in model organisms are expressed in a complex spatial, temporal, and gradient-specific manner that is required for correct antero-posterior patterning and craniofacial development. Otx2 mutations are associated with severe ocular phenotypes and central nervous system abnormalities such as seizures, short stature and developmental delay, CPHD (Combined Pituitary Hormone Deficiency), structural abnormalities of the pituitary gland and early onset retinal dystrophy.
Product Name Alternative
OTX2
Gene Name
OTX2
Gene ID
5015
UniProt
P32243
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant Otx2 protein (amino acids 1-204) was used as the immunogen for this antibody.
Target Antigen
Otx2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL
Isotype
Rabbit IgG

UniProtKB · P32243

Homeobox protein OTX2

OTX2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P32243
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OTX2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RAN5, Q6GTV3, Q9HAW3, Q9P2R1
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Developmental proteinDNA-binding

Disease

Disease variantMicrophthalmia

Domain

Homeobox

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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