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Polyclonal Antibody to HIF2A

CAT: 0793-35-1858-50Size: 50 μLDry Ice: NoHazardous: No
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CAT#:0793-35-1858-50Size:50 μL
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Description
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Product Name Alternative
HLF|| MOP2|| ECYT4|| HIF2A|| PASD2
Gene Name
EPAS1
Gene ID
2034
UniProt
Q99814
Host
Rabbit
Reactivity
Human
Immunogen
Peptide sequence around aa.547-551 (P-E-E-R-L) derived from HumanHIF2A.
Target Antigen
HIF2A
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blotting: 1:500~1:1000
Isotype
Rabbit IgG

UniProtKB · Q99814

Endothelial PAS domain-containing protein 1

EPAS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99814
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPAS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
EPAS-1
EC number
—
Processing
—
Secondary accessions
Q86VA2, Q99630
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Biological process

AngiogenesisDifferentiationHost-virus interactionTranscriptionTranscription regulation

Disease

Congenital erythrocytosisDisease variant

PTM

HydroxylationPhosphoproteinUbl conjugation

Cellular component

Nucleus

Domain

Repeat

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Alternative Products

CatalogName
MBS8573438-01HIF2A Polyclonal Antibody
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GTR18211691HIF2A (N) Antibody, Rabbit Polyclonal
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PHJ47001Anti-HIF2A/EPAS1 Polyclonal Antibody
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