Polyclonal Antibody to Adiponectin

CAT: 0793-35-1833-100Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0793-35-1833-100Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Product Name Alternative

ACDC|| ADPN|| APM1

Gene Name

ADIPOQ

Gene ID

9370

UniProt

Q15848

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide sequence around aa.235~239 (T-G-F-L-L) derived from Human Adiponectin.

Target Antigen

Adiponectin

Clonality

Polyclonal

Applications

Format

Purified

Components

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Applications Notes

Predicted MW: 27kd, Western blotting: 1:500~1:1000

Isotype

Rabbit IgG

UniProtKB · Q15848

Adiponectin

ADIPO_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q15848
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ADIPOQ
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: Q58EX9

Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Domain

CollagenRepeatSignal

Disease

Diabetes mellitusDisease variantObesity

PTM

Disulfide bondGlycoproteinHydroxylation

Molecular function

Hormone

Cellular component

Secreted

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36-3554-100	Anti-Adiponectin (Marker of Obesity) Monoclonal Antibody (Clone: ADPN/1370)
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32-9280-500	Recombinant Human Adiponectin/ACRP30/ADIPOQ (C-6His)
32-9280-50	Recombinant Human Adiponectin/ACRP30/ADIPOQ (C-6His)
32-8312-10	Recombinant Mouse Adiponectin/Acrp30/AdipoQ ((N-6His, E. coli)
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Alternative Products

Catalog	Name
MBS8519032-01	Adiponectin Polyclonal Antibody
APG01574G	Polyclonal Adiponectin Antibody