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Polyclonal Antibody to LSD1

CAT: 0793-11-7004-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0793-11-7004-100Size:100 µg
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Description
LSD1 or KDM1A (lysine (K) -specific demethylase 1A) gene encodes a nuclear protein which contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes. LSD1 or KDM1A is a demethylase that acts on both Lys 4 and 9 of histone H3. Consequently depending upon the use it may act as a co-activator or a co-repressor. It may have a role in the repression of neuronal genes. Two isoforms of LSD1 have been reported which are produced by alternative splicing. LSD1 has more or less ubiquitous expression.
Product Name Alternative
KDM1A||AOF2||KDM1||KIAA0601||LSD1
Gene Name
KDM1A
Gene ID
23028
UniProt
O60341
Host
Rabbit
Reactivity
Mouse, Human
Immunogen
A partial length recombinant LSD1 protein (amino acids 97-328) was used as the immunogen for this antibody.
Target Antigen
LSD1
Clonality
Polyclonal
Applications
IHC, WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 0.5-2.0 μg/mL, Immunohistochemical analysis: 5 μg/mL
Isotype
Rabbit IgG

UniProtKB · O60341

Lysine-specific histone demethylase 1A

KDM1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60341
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KDM1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.11.-, 1.14.11.65, 1.14.99.66
Processing
—
Secondary accessions
A8MWP9, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorDevelopmental proteinOxidoreductaseRepressor

Cellular component

ChromosomeNucleus

Domain

Coiled coil

Disease

Cushing syndromeDisease variant

Ligand

FADFlavoprotein

Biological process

TranscriptionTranscription regulation

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