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LMA2L rabbit pAb

CAT: 0855-ES15142-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15142-01Size:50 µL
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Background
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]
Description
This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016],
UniProt
Q9H0V9
Swiss Prot
Q9H0V9
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human LMA2L AA range: 56-106
Target
LMA2L
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Gene ID (Human)
81562

UniProtKB · Q9H0V9

VIP36-like protein

LMA2L_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H0V9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LMAN2L
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DSH3, D3DXH6, Q53GV3, Q53S67, Q63HN6, Q8NBQ6, Q9BQ14
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Disease variantIntellectual disability

PTM

Disulfide bondGlycoprotein

Cellular component

Endoplasmic reticulumGolgi apparatusMembrane

Ligand

LectinMetal-binding

Technical term

Proteomics identificationReference proteome

Domain

SignalTransmembraneTransmembrane helix

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