Products for Research Use Only
RegisterLogin

Z-APF-CMK

CAT: 0804-HY-P4368Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P4368Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP) [1].
CAS Number
217658-18-9
UNSPSC
12352209
Target
Ser/Thr Protease
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/z-apf-cmk.html
Solubility
H2O
Smiles
ClCC([C@H](CC1=CC=CC=C1)NC([C@H]2N(CCC2)C([C@H](C)NC(OCC3=CC=CC=C3)=O)=O)=O)=O
Molecular Formula
C26H30ClN3O5
Molecular Weight
499.99
References & Citations
[1]Zhang D, et al. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001 May 8;98 (10) :5746-51.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Z-Ala-Pro-Phe-chloromethylketone
CAS Number217658-18-9
PubChem CID92489531
IUPAC Namebenzyl N-[(2S)-1-[(2S)-2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamate
Molecular FormulaC26H30ClN3O5
Molecular Weight500.0
XLogP3.6
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count35
Formal Charge0
Complexity736
SMILES
C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)CCl)NC(=O)OCC3=CC=CC=C3
InChI
InChI=1S/C26H30ClN3O5/c1-18(28-26(34)35-17-20-11-6-3-7-12-20)25(33)30-14-8-13-22(30)24(32)29-21(23(31)16-27)15-19-9-4-2-5-10-19/h2-7,9-12,18,21-22H,8,13-17H2,1H3,(H,28,34)(H,29,32)/t18-,21-,22-/m0/s1
InChIKey
CSTMIHZYNKMFSL-NYVOZVTQSA-N
Chemical Structure
2D Structure
2D structure of Z-Ala-Pro-Phe-chloromethylketone
CAS: 217658-18-9
CID: 92489531
Formula: C26H30ClN3O5
MW: 500.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight500.0
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass499.1873988
Monoisotopic Mass499.1873988
Topological Polar Surface Area105 Ų
Heavy Atom Count35
Formal Charge0
Complexity736
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-W792412Z-YVAD-CMK
HY-W796158-01Z-DEVD-CMK
HY-P4284Z-GGF-CMK
HY-119977-01APF
HY-P10004-01Z-Ala-Ala-Asp-CMK
HY-52101-01CMK
HY-129407AAAF-CMK
HY-P0034-01Ac-DEVD-CMK
HY-129407-01AAF-CMK (TFA)
HY-P5994-01MeOSuc-AAPF-CMK

Alternative Products

CatalogName
MBS5822397Z-APF-CMK
T80660-01Z-DEVD-CMK
T80659-01Z-YVAD-CMK
BML-P165-0001Z-AAD-CMK
T80101-01Z-GGF-CMK
BML-PI124-0005Z-AAF-CMK
112070APF
BUP23888-01Z-Ala-Ala-Asp-CMK
MBS655467-01Granzyme B Inhibitor, Z-AAD-CMK
G8958Granzyme B Inhibitor, Z-AAD-CMK discontinued

Popular Products