TRX-COBI

CAT: 0804-HY-160414-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-160414-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRX-COBI ((R, R) -TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe2+. TRX-COBI has antitumor activity[1].
Product Name Alternative
(R, R) -TRX-COBI; TRX-cobimetinib
UNSPSC
12352005
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trx-cobi.html
Solubility
10 mM in DMSO
Smiles
FC(C=C(C=C1)I)=C1NC(C(F)=C(C=C2)F)=C2C(N3CC([C@H]4N(C(O[C@H]5C[C@]6(OOC7([C@@H](C8)C[C@H]9C[C@@H]8C[C@@H]7C9)O6)CCC5)=O)CCCC4)(O)C3)=O
Molecular Formula
C38H43F3IN3O7
Molecular Weight
837.66
References & Citations
[1]Jiang H, et al. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022 Apr 4;219 (4) :e20210739.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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