TyK2-IN-2

TyK2-IN-2

• CAS Number: 2098466-94-3
• UNSPSC Description: TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases[1].
• Target Antigen: JAK; Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/TYK2-IN-2.html
• Purity: 99.71
• Solubility: DMSO : ≥ 25 mg/mL
• Smiles: CNC1=CC(NC2=CC(C)=CC(C)=C2)=NN3C1=NC=C3C(N)=O
• Molecular Weight: 310.35
• References & Citations: [1]Moslin R, et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported