(R) -Verapamil

• Description :

  (R) -Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275) . (R) -Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R) -Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R) -Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R) -Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp) [1][2][3].

• Product Name Alternative :

  Dexverapamil

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis; Arrestin; Calcium Channel; P-glycoprotein; Potassium Channel; Somatostatin Receptor

• Related Pathways :

  Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Inflammation/Immunology; Metabolic Disease

• Smiles :

  COC(C=C1CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C)C)=C(C=C1)OC

• Molecular Formula :

  C27H38N2O4

• Molecular Weight :

  454.60

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Chen YS, et al. Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models. PLoS One. 2021 Aug 6;16 (8) :e0255405.|[2]Busse D, et al. Cardiovascular effects of (R) - and (S) -verapamil and racemic verapamil in humans: a placebo-controlled study. Eur J Clin Pharmacol. 2006 Aug;62 (8) :613-9. |[3]Luurtsema G, et al. (R) - and (S) -[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation. Nucl Med Biol. 2003 Oct;30 (7) :747-51.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [38321-02-7]