Idebenone-13C, d3

• Description:

  Idebenone-13C, d3 is the deuterium labeled and 13C-labeled Idebenone (HY-N0303) . Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.

• UNSPSC:

  12352211

• Target:

  Apoptosis; Isotope-Labeled Compounds; Mitochondrial Metabolism

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Others

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(C(CCCCCCCCCCO)=C(C1=O)C)C(OC)=C1O[13C]([2H])([2H])[2H]

• Molecular Formula:

  C18 13CH27D3O5

• Molecular Weight:

  342.45

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1189907-75-2]