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Cyclic GMP (sodium) -13C5

CAT: 0804-HY-W767865Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W767865Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclic GMP sodium-13C5 is the 13C-labeled Cyclic GMP sodium. Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=P1(O[13CH2][13C@@H]2[13C@]([H])([13C@H]([13C@@H](O2)N3C=NC4=C3N=C(N)NC4=O)O)O1)O[Na]
Molecular Formula
C5 13C5H11N5NaO7P
Molecular Weight
372.15
References & Citations
[1]Francis SH, et al. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010 Sep;62 (3) :525-63.|[2]Friebe A, et al. cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393 (2) :287-302.|[3]Hartzell HC, et al. Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature. 1986 Sep 18-24;323 (6085) :273-5.|[4]Chintala MS, et al. Cyclic GMP but not cyclic AMP prevents renal platelet accumulation after ischemia-reperfusion in anesthetized rats. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1203-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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