LCC-12 (formate)

• Description:

  LCC-12 (formate) is a copper (II) chelator and a derivative of the biguanide metformin (HY-B0627) . LCC-12 (formate) reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 (formate) reduces IL-1β, IL-2, IL-6, IL-8, and TNF-α levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) levels in primary human cytokine-activated monocyte-derived macrophages (MDMs) . LCC-12 (formate) reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 (formate) improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture[1].

• UNSPSC:

  12352211

• Target:

  Interleukin Related; IRAK; JAK; NADH Dehydrogenase; STAT; TNF Receptor

• Related Pathways:

  Apoptosis; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.9

• Smiles:

  NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO

• Molecular Formula:

  C17H38N10O2

• Molecular Weight:

  414.55

• References & Citations:

  [1]Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617 (7960) :386-394.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported