DG013A (formate)

• Description :

  DG013A (formate) is a phosphinic acid tripeptide mimetic inhibitor. DG013A (formate) displays significantly weak affinity for both ERAP1 (IC50=33 nM) and ERAP2 (IC50=11 nM) . DG013A (formate) can be used for the research of autoimmune disease and cancer[1].

• UNSPSC :

  12352005

• Target :

  Aminopeptidase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Inflammation/Immunology

• Purity :

  99.60

• Smiles :

  O=P([C@@H](N)CCC1=CC=CC=C1)(O)C[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC2=CNC3=CC=CC=C23)=O.O=CO.[0.4]

• Molecular Formula :

  C27H37N4O4P.2/5CH2O2

• Molecular Weight :

  530.99

• References & Citations :

  [1]Birgit Wilding, et al. Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. Bioorg Med Chem Lett. 2021 Jun 15;42:128050.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported